It is a virus infecting liver and is the major cause for chronic liver disease, cirrhosis and liver cancer, particularly in India, Asia and other developing countries. India has more than 37 million HBV infection; about 15–25% of them are likely to suffer from cirrhosis and liver cancer and may die prematurely. Of the 2.6 Crore (26 million) infants born every year in India, approximately 10 Lakhs (1 million) run the life-time risk of developing chronic HBV infection. It’s commonly from mother to baby without any fault and is preventable by simple screening of mother as well as vaccination to newborn. Blood transfusion, surgery, tattoo, multiple sex partners and injectable drug abuse further adds the burden. There is a need for awareness, detection and public health measures to prevent disease transmission and decrease the burden of the disease. The importance is to identify the asymptomatic, hence the World hepatitis day celebration kept the theme “Find the Missing Millions”. We request you all to have tested for hepatitis and ensure vaccine irrespective of age, gennder and comorbidity to prevent this menance.