Know the
AKC Liver Lab
We welcome collaborations that drive innovation, advance research, and improve patient outcomes.
Advancing Liver Science Through Research, Innovation and Global Collaboration
Dr. Ashok Choudhury is a clinician-scientist working at the intersection of hepatology, liver transplantation, clinical research, translational science, product development, artificial intelligence and precision medicine. His research is driven by a clear objective: to transform scientific discoveries into practical, accessible solutions that improve the diagnosis, treatment and outcomes of patients with liver disease.
Translating Research into Clinical Innovation
Research creates its greatest impact when it improves patient care. Dr. Choudhury integrates clinical science, technology, data analytics and multidisciplinary collaboration to develop practical healthcare solutions.
Golden Window in ACLF
Defining the critical phase during acute-on-chronic liver failure when timely intervention may prevent infection, progressive organ failure and death.[ J Gastroenterol Hepatol. 2017 . PMID: 28374414]
AARC Liver Failure Score
Development and clinical application of a prognostic model for risk stratification and outcome prediction in ACLF.[ Hepatol Int. 2017 Aug. PMID: 28856540]
Transplant Window in ACLF
Identifying the appropriate timing and selection criteria for liver transplantation in patients with severe acute-on-chronic liver failure. [Hepatology International. 2021 Oct 4:1-3.]
AI-Based Prediction Models
Developing artificial intelligence models for liver fibrosis, cirrhosis-related renal failure, hepatic encephalopathy and other clinically important outcomes.
CT Radiomics and Non-Invasive Diagnostics
Exploring imaging-based technologies for the non-invasive assessment of portal hypertension and advanced liver disease. [J Clin Exp Hepatol. 2026 PMID: 41550712]
Point-of-Care Innovation
Supporting the development, validation and clinical translation of affordable technologies for rapid and accessible liver-disease assessment.
Product Development and Start-up Ecosystem
Encouraging clinicians, researchers and young innovators to transform scientific ideas into validated medical technologies and patient-centred healthcare products through innovation, incubation and responsible commercialisation.
Advancing Liver Science Through Research, Innovation & Global Collaboration
Dr. Ashok Kumar Choudhury is a clinician-scientist working at the intersection of hepatology, liver transplantation, clinical research, artificial intelligence and precision medicine. His research focuses on translating scientific discoveries into practical solutions that improve diagnosis, treatment and outcomes for patients with complex liver diseases.
Focused Clinical & Translational Research
Our research programme focuses on clinically important problems in hepatology, with an emphasis on improving diagnosis, prediction, treatment and long-term outcomes.
Fatty Liver Disease (MASLD/MASH)
Research addressing non-alcoholic/metabolic fatty liver progression, biomarker identification, non-invasive risk models, and precision therapeutic interventions.
Viral Hepatitis Care
Longitudinal studies on Hepatitis B and C dynamics, viral integration, resistance screening, treatment regimens, and eradication efforts across diverse populations.
Alcohol-Related Liver Disease
Translational research evaluating gut-liver axis dysbiosis, acute alcoholic hepatitis phenotypes, targeted immunomodulation, and early risk stratification.
Advanced Liver Cirrhosis
Investigating portal hypertension mechanics, systemic hemodynamics, decompensation prevention, and critical care management for end-stage liver disease.
Acute-on-Chronic Liver Failure (ACLF)
Elucidating disease pathogenesis, organ failure kinetics, intensive critical care pathways, and defining the "Golden Window" for lifesaving interventions.
Liver Cancer Care
Focusing on hepatocellular carcinoma surveillance, changing molecular patterns, systemic and targeted therapies, and personalized multimodal management protocols.
Liver Transplantation
Evaluating recipient selection criteria, peri-transplant optimization, transplant windows in severe failure, and post-transplant long-term survival outcomes.
Hepatic Encephalopathy & Digital Health
Pioneering clinical AI predictive models, digital health monitoring, non-invasive organ diagnostics, and liver-brain crosstalk analysis in advanced illness.
From Research to Clinical Innovation
Research is meaningful when it can improve the way patients are diagnosed, treated and cared for. Dr. Ashok's work combines clinical research with technology, data science and collaborative networks to address complex problems in liver disease.
Golden Window in ACLF
Developing the concept of the critical period between inflammation and infection in acute-on-chronic liver failure.
AARC Liver Failure Score
Development and application of liver failure prediction models used by clinicians across the world.
AI-Based Liver Disease Models
Artificial intelligence-based approaches for fatty liver detection and non-invasive liver pressure assessment from CT imaging.
Transplant Window in ACLF
Research exploring appropriate timing and selection for liver transplantation in patients with acute-on-chronic liver failure.
Point-of-Care Innovation
Development of emerging point-of-care technologies for rapid and accessible liver disease assessment.
Global Research Collaborations
Complex liver diseases require collaboration beyond geographical boundaries. Dr. Ashok has been involved in large international research networks involving investigators, institutions and centres across Asia and around the world.
CLEARED Consortium
Chronic Liver Disease Evolution and Registry for Events and Decompensation
A global investigator-initiated research platform studying outcomes in patients with chronic liver disease and cirrhosis.
AARC
APASL ACLF Research Consortium
A major Asia-Pacific research collaboration focused on acute-on-chronic liver failure and liver failure outcomes.
APCOLIS
APASL COVID Liver Injury Spectrum Study
A large collaborative effort examining liver injury and outcomes associated with COVID-19.
AHOC
APASL Hepatology and Oncology Consortium
International collaboration focused on hepatology and liver oncology clinical research.
ALCAP
APASL Liver Cancer Preceptorship Program
A platform focused on sharing knowledge and improving clinical education in liver cancer.
Publications & Scientific Contributions
With more than 100 research publications, Dr. Ashok's academic work spans acute-on-chronic liver failure, liver transplantation, metabolic liver disease, liver cancer, critical care and emerging technologies in hepatology.
A global consensus on the critical care management of acute-on-chronic liver failure patients: the APASL ACLF Beijing Position Paper
Comparison of Factors Associated With 30-Day and 90-Day Readmission Among a Global Cohort of Patients Hospitalised With Cirrhosis
Indian National Association for Study of the Liver Guidance Document on Difficult to Treat Autoimmune Hepatitis
Chronic kidney disease in cirrhosis: a study of inpatients from a global perspective
Acute-on-chronic liver failure: pathophysiological mechanisms and clinical management
Liver Failure, Hepatic Encephalopathy, and Infection Contribute to Mortality Risk in a Global Cirrhosis Cohort
Enhancement of Inpatient Mortality Prognostication With Machine Learning in a Prospective Global Cohort of Patients With Cirrhosis With External Validation
Lack of association between rifaximin and drug-resistant infections: a global multicenter inpatient cirrhosis cohort
Be Part of the Future of Liver Care
We are actively working on innovative clinical research and multidisciplinary projects focused on advancing hepatology, liver transplantation, artificial intelligence, and precision medicine. We welcome collaborations with clinicians, researchers, data scientists, PhD scholars, and students passionate about transforming healthcare.
Current Areas: Clinical Research • AI in Hepatology • Digital Health • Precision Medicine • Multi-omics
Global Research Collaborations
Complex liver diseases require collaboration beyond geographical boundaries. Dr. Choudhury has contributed to international investigator networks connecting institutions across India, the Asia-Pacific region and the wider world.
CLEARED Consortium
Chronic Liver Disease Evolution and Registry for Events and Decompensation
Role: Principal InvestigatorA global investigator-initiated platform studying the evolution, complications, healthcare utilisation and outcomes of chronic liver disease and cirrhosis.
- 37 countries
- More than 130 participating centres
AARC
APASL ACLF Research Consortium
Role: Principal CoordinatorA major Asia-Pacific collaborative network investigating acute-on-chronic liver failure, organ failure, prognostication, critical care and transplantation.
- 22 countries
- More than 97 participating centres
APCOLIS
APASL COVID-19 Liver Injury Spectrum Study
Role: Principal InvestigatorA large international study evaluating the spectrum, determinants and clinical outcomes of liver injury associated with COVID-19.
AHOC
APASL Hepatology and Oncology Consortium
Role: India CollaboratorAn international research collaboration advancing clinical research and evidence-based care in hepatology and liver oncology.
ALCAP
APASL Liver Cancer Preceptorship Programme
Role: Course Coordinator—AsiaAn educational platform promoting knowledge exchange, clinical training and capacity-building in liver cancer care.
Research Impact
Dr. Choudhury’s scientific work spans acute-on-chronic liver failure, cirrhosis, liver transplantation, metabolic liver disease, liver cancer, critical care and emerging healthcare technologies.
Highly Cited Publications with Impact Factor
Sarin SK, Choudhury A, Kumar A, Mahmud N, Lee GH, Ning Q, Tan SS, Thanapirom K, Arora V, Nakayama N, Li J, Karvellas CJ. Acute-on-chronic liver failure: pathophysiological mechanisms and clinical management.
Sarin SK, Choudhury A. Acute-on-chronic liver failure: terminology, mechanisms and management.
Kulkarni AV, Sarin SK, Choudhury A, Angeli P, Moreau R, Bajaj JS. Harmonizing ACLF definition: Why is it essential for scientific progress?.
Bajaj JS, Choudhury A, Xie Q, Kamath PS, Topazian M, Hayes PC, Torre A, Desalegn H, Idilman R, Cao Z, Alvares-da-Silva MR, George J, Bush BJ, Thacker LR, Wong F; CLEARED Investigators. Global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium.
Silvey S, Kamath PS, George J, Choudhury A, Xie Q, Topazian M, Mekonnen HD, Cao Z, Nagral A, Reddy KR, Adebayo D, Asrani SK, Rajoriya N, Bajaj JS et.al. CLEARED Investigators. Enhancement of Inpatient Mortality Prognostication With Machine Learning in a Prospective Global Cohort of Patients With Cirrhosis With External Validation.
Bajaj JS, Shawcross DL, Choudhury A, Karvellas CJ, O'Leary JG, Trebicka J, Kulkarni AV, Marciano S, Asrani SK, Premkumar M, Thabut D, Xie Q, Sonderup M, Strasser SI, Faria AQ, Alvares-da-Silva MR, Torre A, Lai JC, Ning Q, Verma N, Chirapongsathorn S, Mendizabal M, Treeprasertsuk S, Bernal W, VanWagner LB, Maiwall R, Piano S, Albillos A, Garcia-Tsao G, Angeli P, Reddy KR, Wong F, Moreau R, Sarin SK, Kamath PS. Defining Organ Failures in Patients With Cirrhosis: Consensus Statements.
Sarin SK, Philips CA, Kamath PS, Choudhury A, Maruyama H, Nery FG, Valla DC. Toward a Comprehensive New Classification of Portal Vein Thrombosis in Patients With Cirrhosis.
Wong F, Adebayo D, George J, Idilman R, Hayes PC, Alvares-da-Silva MR, Torre A, Mekonnen HD, Seto WK, Sarin SK, Cao Z, Rajoriya N, Nagral A, Fisseha H, Kulkarni AV, Zhu C, Debzi N, Farias AQ, Su M, Goel A, Marciano S, Livingstone R, Dhiman RK, Gao Y, Malé-Velázquez R, Demitars CO, Bera C, Jiang YF, Velarde-Ruiz Velasco JA, Tan HK, Zhao C, Huezo MSG, Asrani SK, Wang L, Lu M, Michalczuk MT, Barutcu S, Cordova-Gallardo J, Gofton C, Gounder M, Shaw J, Albhaisi S, Zheng X, Aravinthan A, Rajaram RB, Jothimani D, Thanapirom K, Benitez C, Dincer D, Saraya A, Xu B, Lin M, Wu X, Liu C, Reddy R, Bush B, Thacker LR, Topazian M, Xie Q, Silvey S, Kamath PS, Choudhury A, Bajaj JS; CLEARED Investigators. Chronic kidney disease in cirrhosis: a study of inpatients from a global perspective.
Bajaj JS, Kamath PS, Wong F, Xie Q, Idilman R, Topazian M, Seto WK, Torre A, Hayes P, George P, Alvares-da-Silva M, Bush BJ, Silvey S, Choudhury A; CLEARED Investigators. Lack of association between rifaximin and drug-resistant infections: a global multicenter inpatient cirrhosis cohort.
Wang Y, Oza N, Leo J, Choudhury A, Huang DQ. Burden of alcohol use disorder, alcohol-related liver disease, and alcohol-related liver cancer: Editorial on "Global epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000-2021.
Jain P, Shasthry SM, Choudhury AK, Maiwall R, Kumar G, Bharadwaj A, Arora V, Vijayaraghavan R, Jindal A, Sharma MK, Bhatia V, Sarin SK. Alcohol associated liver cirrhotics have higher mortality after index hospitalization: Long-term data of 5,138 patients.
Anand L, Choudhury A et.al. APASL ACLF (APASL ACLF Research Consortium) Working Party. Flare of Autoimmune Hepatitis Causing Acute on Chronic Liver Failure: Diagnosis and Response to Corticosteroid Therapy.
Bajaj JS, Silvey S, Mullan A, Choudhury A, Wong F, George J, Idilman R, Topazian M, Seto WK, Torre A, Hayes P, Thacker LR, Bush BJ, Alvares da Silva M, Xie Q, Kamath PS; CLEARED Investigators. Liver Failure, Hepatic Encephalopathy, and Infection Contribute to Mortality Risk in a Global Cirrhosis Cohort.
Bajaj JS, Choudhury A, Kumaran V, Wong F, Seto WK, Alvares-Da-Silva MR, Desalgn H, Hayes PC, Idilman R, Topazian M, Torre A, Xie Q, George J, Kamath PS. Geographic disparities in access to liver transplant for advanced cirrhosis: Time to ring the alarm!.
Wang Y, Chen R, Lee SY, Tan EXX, Muthiah M, Yu Z, Teng MLP, Leo J, Ng CH, Choudhury A, Huang DQ. Rising burden of steatotic liver disease in women of childbearing age and projections to 2035.
Kumar A, Arora A, Choudhury A et.al. APASL ACLF Research Consortium (AARC) for APASL ACLF Working Party. Impact of Diabetes, Drug-Induced Liver Injury, and Sepsis on Outcomes in Metabolic Dysfunction Associated Fatty Liver Disease-Related Acute-on-Chronic Liver Failure.
Devarbhavi H, Choudhury AK et.al. APASL ACLF working party. Drug-Induced Acute-on-Chronic Liver Failure in Asian Patients.
Chen T, Choudhury A, Liu W, Zhang M, Wu W, Xiang H, Wang X, Jia J, Ormeci N, Wei L, Omata M, Kwo PY, Sarin SK, Ning Q et.al.; APASL-ACLF Research Consortium (AARC) for APASL-ACLF Working Party. A global consensus on the critical care management of acute-on-chronic liver failure patients: the APASL ACLF Beijing Position Paper.
Choudhury A, Kulkarni AV, …Wei L, Omata M, Sarin SK et.al. for APASL-ACLF Research Consortium (AARC) for APASL-ACLF working party. Acute-on-chronic liver failure (ACLF): the 'Kyoto Consensus'-steps from Asia.
Wang Y, Oza N, Chirapongsathorn S, Lee SY, Tan EXX, Lee GH, Teng MLP, Leo J, Ng C, Ng CH, Choudhury A, Aw M, Muthiah M, Huang DQ. Rising burden of metabolic dysfunction-associated steatotic liver disease in adolescents aged 15-19 years and projections to 2035.
Choudhury A, Rajaram R, Sarin SK. Acute-on-chronic liver failure in metabolic dysfunction-associated fatty liver disease patients: a disease multiplier.
Kim DS, Yoon YI, Kim BK, Choudhury A, Kulkarni A, Park JY, Kim J, Sinn DH, Joo DJ, Choi Y, Lee JH, Rela M, Lin HC, Omata M, Sarin SK et.al.; for Asian Pacific Association for Study of Liver (APASL). Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation.
Maiwall R, Pasupuleti SSR, Choudhury A, Kim DJ et.al.. AARC score determines outcomes in patients with alcohol-associated hepatitis: a multinational study.
Sharma S, Agarwal S, Saraya A, Choudhury A et.al. APASL ACLF Research Consortium (AARC) for APASL ACLF working party. Identifying the early predictors of non-response to steroids in patients with flare of autoimmune hepatitis causing acute-on-chronic liver failure.
Sharma S, Agarwal S, Saraya A, Choudhury A, Mahtab MA, Alam MS, Saigal S, Kim DJ, Eapen CE, Goel A, Ning Q, Devarbhavi H, Singh V, Shukla A, Hamid S, Hu J, Tan SS, Arora A, Sahu MK, Rela M, Jothimani D, Rao PN, Kulkarni A, Ghaznian H, Lee GH, Zhongping D, Sood A, Goyal O, Lesmana LA, Lesmana RC, Treeprasertsuk S, Yuemin N, Shah S, Tao H, Dayal VM, Shaojie X, Karim F, Abbas Z, Sollano JD, Kalista KF, Shreshtha A, Payawal D, Omata M, Sarin SK; APASL ACLF Research Consortium (AARC) for APASL ACLF Working Party. Acute variceal bleeding portends poor outcomes in patients with acute-on-chronic liver failure: a propensity score matched study from the APASL ACLF Research Consortium (AARC).
Sarin SK, Choudhury A et.al. APASL ACLF Research Consortium (AARC) for APASL ACLF working Party.. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.
Pan Z, Khatry MA, Yu ML, Choudhury A, Sebastiani G, Alqahtani SA, Eslam M. MAFLD: an ideal framework for understanding disease phenotype in individuals of normal weight.
Choudhury A, Kedarisetty CK, Vashishtha C, Saini D, Kumar S, Maiwall R, Sharma MK, Bhadoria AS, Kumar G, Joshi YK, Sarin SK. A randomized trial comparing terlipressin and noradrenaline in patients with cirrhosis and septic shock.
Idilman R, Haktaniyan B, Choudhury A, Wong F, Kamath PS, Xie Q, Topazian M, Hayes PC, Alvares-da-Silva MR, Torre A, George J, Seto WK, Bush B, Silvey S, Thacker LR, Bajaj JS; CLEARED Investigators. Comparison of Factors Associated With 30-Day and 90-Day Readmission Among a Global Cohort of Patients Hospitalised With Cirrhosis.
Kumar SE, Sithamparapillai K, Choudhury A, Bharadwaj PK, Trebicka J, Karvellas CJ, Arab JP, Premkumar PS, Eapen CE, Goel A. Therapeutic Plasma Exchange in Patients With Acute-On-Chronic Liver Failure Improves Survival-An Updated Meta-Analysis.
Verma N, Choudhury A, Singh V, Duseja A, Al-Mahtab M, Devarbhavi H, Eapen CE, Goel A, Ning Q, Duan Z, Hamid S, Jafri W, Butt AS, Shukla A, Tan SS, Kim DJ, Hu J, Sood A, Goel O, Midha V, Ghaznian H, Sahu MK, Lee GH, Treeprasertsuk S, Shah S, Lesmana LA, Lesmana RC, Prasad VGM, Sarin SK; APASL ACLF Research Consortium (AARC) for APASL ACLF Working Party. APASL-ACLF Research Consortium-Artificial Intelligence (AARC-AI) model precisely predicts outcomes in acute-on-chronic liver failure patients.
Giri S, Ingawale S, Khatana G, Gore P, Praharaj DL, Wong VW, Huang DQ, Singhal A, Choudhury A. Metabolic Cause of Cirrhosis Is the Emerging Etiology for Primary Liver Cancer in the Asia-Oceania Region: Analysis of Global Burden of Disease (GBD) Study 2021.
Choudhury A, Kumar M, Sharma BC, Maiwall R, Pamecha V, Moreau R, Chawla YK, Duseja A, Mahtab M, Rahman S, Hamid SS, Butt AS, Jafri W, Tan SS, Devarbhavi H, Amarapurkar D, Ning Q, Eapen CE, Goel A, Kim DJ, Ghazinyan H, Shiha G, Lee GH, Abbas Z, Payawal DA, Dokmeci AK, Yuen MF, Lesmana LA, Sood A, Chan A, Lau GK, Jia JD, Duan Z, Yu C, Yokosuka O, Jain P, Bhadoria AS, Kumar G, Sarin SK; APASL ACLF working party. Systemic inflammatory response syndrome in acute-on-chronic liver failure: Relevance of 'golden window': A prospective study.
Thanapirom K, Treeprasertsuk S, Choudhury A et.al. Ammonia is associated with liver-related complications and predicts mortality in acute-on-chronic liver failure patients.
Choudhury A, Roy A, Mukund A, Sharma D, Heo S, Choi WM. Managing Complex Hepatocellular Carcinoma Subtypes: Diffuse Infiltrative, Large Tumours, and Tumour Rupture-The Challenges and Strategies.
Choudhury A, Adali G, Kaewdech A, Giri S, Kumar R. Liver Transplantation in Chronic Liver Disease and Acute on Chronic Liver Failure- Indication, Timing and Practices.
Choudhury A, Singh SP, Desmukh A, Sahoo B, Eslam M. Post-Liver Transplant Metabolic Syndrome.
Jarrah M, Bourque S, Choudhury A, Singal AG. Hepatocellular carcinoma: new insights into prevention and surveillance.
Academic Mentorship
Research leadership is not measured by publications alone. It also involves mentoring young physicians, developing independent researchers and creating future academic leaders. Dr. Choudhury has guided:
Global Academic Engagements
Dr. Choudhury has contributed to international scientific meetings, consensus development, research collaborations and educational forums across Asia, Europe and North America. His academic engagement includes major international societies.
Professional and Scientific Society Engagement
American Association for the Study of Liver Diseases
European Association for the Study of the Liver
Asian Pacific Association for the Study of the Liver
International Liver Transplantation Society
Indian National Association for Study of the Liver
Liver Transplant Society of India
Indian Society of Gastroenterology
Society of Gastrointestinal Endoscopy of India
Indian Association for Parenteral and Enteral Nutrition
Editorial Roles
- Journal of Clinical and Experimental Hepatology — Guest Editor
- Journal of Clinical and Translational Hepatology — Academic Editor
- World Journal of Gastroenterology — Academic Editor
- Hepatology Forum — Academic Editor
- Therapeutic Advances in Gastroenterology — Guest Editor
- Medical Journal of Viral Hepatitis — Academic Editor
Academic Leadership and Administration
- Associate Dean, International Affairs, ILBS.
- Member Secretary, Technology Research and Industrialization Cell (TRIC), ILBS.
- Former Governing Council Member, Indian National Association for Study of the Liver (INASL).
- Principal Investigator, CLEARED Consortium, involving 27 countries and 115 centres worldwide.
- Principal Coordinator, APASL ACLF Research Consortium (AARC), involving 22 countries and 97 centres across the Asia-Pacific region.
- Organizing Secretary, International Liver Cancer Course, 2023 and 2024.
Consult or Collaborate
For clinical consultation, academic collaboration, multicentre research, innovation or mentorship:
Ready to consult or collaborate on liver research? Email us at ashokliverdoc@gmail.com or Make an Appointment.